UPDATED DRUGS AND THEIR DOSAGES FOR CHILDREN IN MG/KG BW

UPDATED DRUGS AND THEIR DOSAGES FOR CHILDREN IN MG/KG BWT

1. Paracetamol: 10-15mg/kg 4-6hrly 2. Frusemide: 1-2mg/kg dly 3. Ceftriaxone: 80mg/kg dly or in two divided doses For meningitis: 50mg/kg 12hrly or 100mg/kg dly 4. Diazepam: PR - 0.5mg/kg in children stat. IV - 0.25mg/kg in children stat 5. Phenobarbital: IM; 15mg/kg loading dose Oral/IM maintenance: 2.5-5mg/kg. NB: 20mg/kg in infants <2wks IV 6. Phenytoin: 18mg/kg as loading dose IV 7. Quinine: Oral/IM - 10mg/kg 8hrly. IV - 20mg/kg as loading dose, then 10mg/kg bwt 8hrly 8. AS/AQ: 4mg/kg of artesunate and 10mg/kg of amodiaquine dly or in 2 divided doses 9. Erythromycin Oral: 12.5mg/kg 6hrly 10. Azithromycin oral: 20mg/kg dly 11. Ciprofloxacin oral/IV: 10-20mg/ kg per dose 12hrly 12. Metronidazole IV/oral: 7.5mg/kg 8hrly but 10mg/kg in giardiasis 13. Prednisolone oral: 1mg/kg twice dly 14. IV Aminophylline: Loading dose: 6mg/kg slowly over 20mins. Maintenance dose: 5mg/kg up to 6hrly 15. Amoxicillin oral or IV: 25mg/kg twice daily. For pneumonia: 40mg/kg 2x dly 16. IM/IV Ampicillin: 50mg/kg 6hrly 17. IM Artemether: 3.2mg/kg as loading dose then 1.6mg dly 18. IV/IM Artesunate: 2.4mg/kg at 0, 12 and 24hrs followed by 2.4mg/kg dly when necessary 19. Artemether-lumefantrine oral: 2mg/kg artemether plus 12mg/kg lumefantrine twice dly. NB: Don't give in <5kg or <6months 20. Cefotaxime IV: 50mg/kg 6hrly 21. Cefalexin Oral/IV: 12.5mg/kg 6hrly 22. Chloramphenicol IM/IV/Oral: 20-25mg/kg 6hrly 23. Flucloxacillin IM/IV: 25-50mg 6hrly 24. Cotrimoxazole (septrin) Oral: 4mg/kg trimethoprim + 20mg/kg sulfamethoxazole 2x dly 25. Digoxin Oral: 15mcg/kg loading dose then 5mcg/kg 12hrly of maintenance dose to be started 6hrs after loading dose 26. Fluconazole Oral: 3-6mg/kg 27. Furazolidone oral: 1.25mg/kg 4x dly 28. Gentamicin IM/IV: 2.5mg/kg 8hrly or 7.5mg/kg dly 29. Ibuprofen oral: 5-10mg/kg 6-8hrly 30. Metoclopramide IV/IM/Oral: 0.1-0.2mg/kg 8hrly 31. Morphine: IM; 0.1-0.2mg/kg 4-6hrly. IV; 0.05-0.1mg/kg 4-6hrly 32. Benzathine penicillin IM: 50,000iu/kg dly 33. Benzyl penicillin (X'pen): IM/IV; 50,000iu/kg 6hrly. But 100,000iu/kg 6hrly in meningitis 34. Procaine penicillin IM: 50,000iu/kg dly 35. Potassium chloride IV: 2-4mmol/kg per day 36. Tetracycline oral: 12.5mg/kg 6hrly NB: Stains teeth in children 37. Ketamine: IM loading dose; 5-8mg/kg and 1-2mg/kg for further dose. IV loading dose: 1-2mg/kg and a further 0.5-1mg/kg PRN References: 1. WHO pocketbook of hospital care for children, 2nd edition, 2013 2. WHO practical handbook for the management of severe malaria, 3rd edition, 2012UPDATED DRUGS AND THEIR DOSAGES FOR CHILDREN IN MG/KG BWT 1. Paracetamol: 10-15mg/kg 4-6hrly 2. Frusemide: 1-2mg/kg dly 3. Ceftriaxone: 80mg/kg dly or in two divided doses For meningitis: 50mg/kg 12hrly or 100mg/kg dly 4. Diazepam: PR - 0.5mg/kg in children stat. IV - 0.25mg/kg in children stat 5. Phenobarbital: IM; 15mg/kg loading dose Oral/IM maintenance: 2.5-5mg/kg. NB: 20mg/kg in infants <2wks IV 6. Phenytoin: 18mg/kg as loading dose IV 7. Quinine: Oral/IM - 10mg/kg 8hrly. IV - 20mg/kg as loading dose, then 10mg/kg bwt 8hrly 8. AS/AQ: 4mg/kg of artesunate and 10mg/kg of amodiaquine dly or in 2 divided doses 9. Erythromycin Oral: 12.5mg/kg 6hrly 10. Azithromycin oral: 20mg/kg dly 11. Ciprofloxacin oral/IV: 10-20mg/ kg per dose 12hrly 12. Metronidazole IV/oral: 7.5mg/kg 8hrly but 10mg/kg in giardiasis 13. Prednisolone oral: 1mg/kg twice dly 14. IV Aminophylline: Loading dose: 6mg/kg slowly over 20mins. Maintenance dose: 5mg/kg up to 6hrly 15. Amoxicillin oral or IV: 25mg/kg twice daily. For pneumonia: 40mg/kg 2x dly 16. IM/IV Ampicillin: 50mg/kg 6hrly 17. IM Artemether: 3.2mg/kg as loading dose then 1.6mg dly 18. IV/IM Artesunate: 2.4mg/kg at 0, 12 and 24hrs followed by 2.4mg/kg dly when necessary 19. Artemether-lumefantrine oral: 2mg/kg artemether plus 12mg/kg lumefantrine twice dly. NB: Don't give in <5kg or <6months 20. Cefotaxime IV: 50mg/kg 6hrly 21. Cefalexin Oral/IV: 12.5mg/kg 6hrly 22. Chloramphenicol IM/IV/Oral: 20-25mg/kg 6hrly 23. Flucloxacillin IM/IV: 25-50mg 6hrly 24. Cotrimoxazole (septrin) Oral: 4mg/kg trimethoprim + 20mg/kg sulfamethoxazole 2x dly 25. Digoxin Oral: 15mcg/kg loading dose then 5mcg/kg 12hrly of maintenance dose to be started 6hrs after loading dose 26. Fluconazole Oral: 3-6mg/kg 27. Furazolidone oral: 1.25mg/kg 4x dly 28. Gentamicin IM/IV: 2.5mg/kg 8hrly or 7.5mg/kg dly 29. Ibuprofen oral: 5-10mg/kg 6-8hrly 30. Metoclopramide IV/IM/Oral: 0.1-0.2mg/kg 8hrly 31. Morphine: IM; 0.1-0.2mg/kg 4-6hrly. IV; 0.05-0.1mg/kg 4-6hrly 32. Benzathine penicillin IM: 50,000iu/kg dly 33. Benzyl penicillin (X'pen): IM/IV; 50,000iu/kg 6hrly. But 100,000iu/kg 6hrly in meningitis 34. Procaine penicillin IM: 50,000iu/kg dly 35. Potassium chloride IV: 2-4mmol/kg per day 36. Tetracycline oral: 12.5mg/kg 6hrly NB: Stains teeth in children 37. Ketamine: IM loading dose; 5-8mg/kg and 1-2mg/kg for further dose. IV loading dose: 1-2mg/kg and a further 0.5-1mg/kg PRN References: 1. WHO pocketbook of hospital care for children, 2nd edition, 2013 2. WHO practical handbook for the management of severe malaria, 3rd edition, 2012